Fetal hemoglobin-containing erythrocytes. I. Counts of cells stained by the acid elution method compared with alkali denaturation measurements.

نویسندگان

  • K A KIOSSOGLOU
  • I J WOLMAN
  • M GARRISON
چکیده

AND MORTIMER GARRISON, JR. T HERE IS considerable interest currently with respect to the acid elution metho)d of Kleihauer, Braun and Betke1 for detecting cytologically those circulating erythrocytes which have an appreciable content of fetal hemoglobin (“F-containing cells” ) . The method is based on the lower solubility of alkaliresistant or fetal hemoglobin in an acid environment as compared with that of normal adult hemoglobin. This communication compares the counts of F-containing cells obtained by the acid elution method with simultaneous measurements of alkali-resistant hemoglobin in a variety of hematologic conditions including thalassemia major and mmor, aplastic anemia, leukemia and normal controls.

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عنوان ژورنال:
  • Blood

دوره 21  شماره 

صفحات  -

تاریخ انتشار 1963